This project, based on the serothèque created within the framework of the Dielmo / Ndiop project, aims to analyze the immunological responses that have accompanied the epidemiological changes resulting from control strategies over the past ten years, particularly the installation of impregnated mosquito nets. insecticides in June 2008. These interventions had a significant impact on morbidity. The aim is to determine markers, exposure, transmission and / or protection based on the serum and clinical data collected over more than 20 years.

Various studies have shown a significant drop in seroprevalence between 2000 and 2010 as well as a change in the profile of the seroprevalence in Dielmo, the profile of which is similar to that of Ndiop. It has also been shown to decrease the intensity of responses as well as a loss of acquired immunity in parallel with a delay in the acquisition of immunity.

In addition, mathematical modeling work on the evolution of antibody responses directed against Plasmodium falciparum antigens was carried out in collaboration with Gaston Berger University as part of a thesis work in Applied Mathematics. These studies validated the use of antibody responses to crude Plasmodium falciparum extract as a tool for assessing the level of exposure to malaria, particularly in areas of low transmission.